TY - JOUR
T1 - Metagenomics and development of the gut microbiota in infants
AU - Vallés, Y.
AU - Gosalbes, M.J.
AU - de Vries, Lisbeth Elvira
AU - Abellán, J.J.
AU - Francino, M.P
N1 - Funding Information:
We thank Ferran Ballester and the INMA project (Infancia y Medio Ambiente) for providing meconium samples, Loreto Ferrús for her laboratory work, Nuria Jiménez, Llúcia Martínez and Alejandro Artacho for pyrosequencing and bioinformatic processing of sequence data at CSISP, and Feng Chen and his Sequencing Technology Group for pyrosequencing and data processing at the DOE Joint Genome Institute. Financial support was received from the US National Institutes of Health (project R0lDK066288) and the Spanish MICINN (project SAF2009-13032-C02-02 and project CSD2009-00006 of the CONSOLIDER program).
PY - 2012/7
Y1 - 2012/7
N2 - The establishment of a balanced intestinal microbiota is essential for numerous aspects of human health, yet the microbial colonization of the gastrointestinal tract of infants is both complex and highly variable among individuals. In addition, the gastrointestinal tract microbiota is often exposed to antibiotics, and may be an important reservoir of resistant strains and of transferable resistance genes from early infancy. We are investigating by means of diverse metagenomic approaches several areas of microbiota development in infants, including the deployment of functional capabilities at the community level, the presence of antibiotic resistances and the population dynamics of the most abundant genera.
AB - The establishment of a balanced intestinal microbiota is essential for numerous aspects of human health, yet the microbial colonization of the gastrointestinal tract of infants is both complex and highly variable among individuals. In addition, the gastrointestinal tract microbiota is often exposed to antibiotics, and may be an important reservoir of resistant strains and of transferable resistance genes from early infancy. We are investigating by means of diverse metagenomic approaches several areas of microbiota development in infants, including the deployment of functional capabilities at the community level, the presence of antibiotic resistances and the population dynamics of the most abundant genera.
KW - Antibiotics
KW - Faeces
KW - Intestinal microbiota
KW - Meconium
KW - Metagenomics
UR - https://www.scopus.com/pages/publications/84861675361
U2 - 10.1111/j.1469-0691.2012.03876.x
DO - 10.1111/j.1469-0691.2012.03876.x
M3 - Journal article
SN - 1469-0691
VL - 18
SP - 21
EP - 26
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - SUPPL. 4
ER -