Abstract
Introduktion:
The purpose of the study was to investigate a possible correlation between Dynamic Contrast Enhanced Computer Tomography (DCE-CT) of colorectal liver metastases and 1) the plasma level of different forms of the urokinase plasminogen activation receptor (uPAR), and 2) the histological microvessel density (MVD).
Materiale og metode:
Twenty-eight patients referred to liver surgery for colorectal liver metastases were invited and 11 patients fulfilled all criteria for comparative analyses. A plasma sample for analysis of uPAR was collected and a DCE-CT was performed the day before liver surgery. Image analysis was performed at a workstation for perfusion imaging, encompassing measurements of the arterial and portal tissue perfusion (AF, PF) and Perfusion Index (PI = AF/(AF+PF)%) of the metastases. MVD was evaluated histologically in the periphery the metastases. The Spearman correlation test was used for statistical analysis.
Resultater:
A high PI value was significantly correlated to a high MVD (r=0.75, p=0.01). The PI and the portal flow of the metastases were significantly higher than the surrounding normal liver parenchyma. No significant correlation was found between the DCE-CT values.
Konklusion:
Thus, a correlation between DCE-CT characteristics and MVD in liver metastases was observed, prompting further investigations in a larger series of patients.
The purpose of the study was to investigate a possible correlation between Dynamic Contrast Enhanced Computer Tomography (DCE-CT) of colorectal liver metastases and 1) the plasma level of different forms of the urokinase plasminogen activation receptor (uPAR), and 2) the histological microvessel density (MVD).
Materiale og metode:
Twenty-eight patients referred to liver surgery for colorectal liver metastases were invited and 11 patients fulfilled all criteria for comparative analyses. A plasma sample for analysis of uPAR was collected and a DCE-CT was performed the day before liver surgery. Image analysis was performed at a workstation for perfusion imaging, encompassing measurements of the arterial and portal tissue perfusion (AF, PF) and Perfusion Index (PI = AF/(AF+PF)%) of the metastases. MVD was evaluated histologically in the periphery the metastases. The Spearman correlation test was used for statistical analysis.
Resultater:
A high PI value was significantly correlated to a high MVD (r=0.75, p=0.01). The PI and the portal flow of the metastases were significantly higher than the surrounding normal liver parenchyma. No significant correlation was found between the DCE-CT values.
Konklusion:
Thus, a correlation between DCE-CT characteristics and MVD in liver metastases was observed, prompting further investigations in a larger series of patients.
| Originalsprog | Engelsk |
|---|---|
| Titel | Abstract book : Frie foredrag, videnskabelige posters og kasuistiske posters |
| Forlag | Dansk Radiologisk Selskab |
| Publikationsdato | 24 jan. 2018 |
| Sider | 8 |
| Status | Udgivet - 24 jan. 2018 |
| Begivenhed | Dansk Radiologisk Selskabs årsmøde - Odense, Danmark Varighed: 24 jan. 2018 → 26 jan. 2018 |
Konference
| Konference | Dansk Radiologisk Selskabs årsmøde |
|---|---|
| Land/Område | Danmark |
| By | Odense |
| Periode | 24/01/18 → 26/01/18 |
Emneord
- radiografi