Projects per year
Personal profile
Research and development areas
In the early stages of my career, I focused on establishing methodologies across various domains within antibody technology, including phage display of antibodies, antibody expression in prokaryotic and eukaryotic cells, antibody purification, in vitro assays, and maternofetal transplacental transport of recombinant antibodies. My research primarily targeted blood type antigen RhD and malaria antigen MSP-3.
Antibodies against RhD demonstrated in vitro efficacy comparable to conventional Rhesus prophylaxis in preventing Hemolytic disease of the Fetus and Newborn. Antibodies against MSP-3 exhibited promising results, resulting in a global patent and the foundation of a company where I serve as the board chairman and co-founder.
In parallel, I contributed to developing methodologies for prenatal prediction of fetal blood types using qPCR and Next-Generation Sequencing, still in clinical use. I also delved into droplet digital PCR testing of donor derived cell-free DNA as a noninvasive marker for allograft health, nearing validation for clinical application.
Currently my research centers around hemostasis and Point-of-Care Testing (POCT). While investigating the impact of pneumatic tube transport on blood samples and its influence on global hemostasis and platelet function, I gained insights into the benefits of Point-of-Care Testing (POCT) as opposed to centralized testing.
Collaborating with various partners in POCT, I recently concluded a project, "Equality in health through self-monitoring of data," funded by Danish Life Science Cluster. This experience, coupled with my expertise, has fueled my plan to develop “Advanced POCT for Detecting Thrombotic Risk and Bleeding Tendencies”, combining my interests in POCT, hemostasis, and methodological innovation.
Competences
Linguistic competences:Language: Danish
Level: Native speaker
Language: English
Level: Negotiation level
Language: Swedish
Level: Negotiation level
Language: Norwegian
Level: Negotiation level
Organisational unit competences:
Project management: Several years of experience
Networking: Several years of experience
Fundraising: Several years of experience
Administration: Some experience
Management: Some experience
Education/Academic qualification
Ph.D. , University of Copenhagen
Award Date: 1 Jan 2006
MSc., University of Copenhagen
Award Date: 1 Oct 1995
Project manager, Danske Ingeniørers Efteruddannelse Mannaz (tidl. DIEU)
… → Dec 2013
Positions
Project manager and scientific researcher , Kennedy Center
1 Nov 1995 → 14 Sept 2013
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- 6 Similar Profiles
Collaborations and top research areas from the last five years
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Analyse af kortisol ekstraheret fra hår - Validering og metodeoptimering
Smith, J. (Principle researcher), Lindqvist, D. (Co-researcher), Nielsen, L. K. (Co-researcher) & Martinez, J. B. (Co-researcher)
01/07/24 → 01/07/25
Project: Development project/ Innovation
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Validering og kvalitetssikring af ny hjemmetest - Point of care TSH-test
Høgdall, D. (Principle researcher), Smith, J. (Principle researcher), Nielsen, L. K. (Principle researcher), Jørgensen, S. F. (Principle researcher), Bonnema, S. (Co-researcher) & Svendsen, W. (Principle researcher)
01/01/22 → …
Project: Research
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Beroligende behandling til adfærdsforstyrrede og urolige plejehjemsbeboere med demens – et pilotprojekt
Jensen, J. (Principle researcher), Houmann, M. (Co-researcher), Uth, J. B. (Co-researcher), Nielsen, L. K. (Co-researcher), Smith, J. (Co-researcher), Zebis, M. K. (Principle researcher) & Ettrup, B. (Co-researcher)
01/08/18 → …
Project: Research
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Lighed i personlig sundhed ved selvmonitorering af data
Nielsen, L. K. (Principle researcher), Hansen, H. (Co-researcher), Jacobsen, D. (Co-researcher), Smith, J. (Co-researcher), Heiberg, T. (Co-researcher), Thomasen, I. N. (Co-researcher), Madsen, K. V. (Co-researcher), Vigsnæs, L. K. (Co-researcher), Larsen, J. M. (Co-researcher), Ellegaard, M. (Co-researcher), Krintel, L. R. (Co-researcher), Bentzen, H. F. B. (Co-researcher), Markussen, P. (Co-researcher), Carlson, M. (Principle researcher), Pyndt, S. (Co-researcher), Lydike, P. (Principle researcher), Dahm, C. L. (Co-researcher), Warthoe , P. (Co-researcher), Højlund-Nielsen, E. (Co-researcher), Høgdall, D. (Co-researcher), Schou , L. H. (Co-researcher), Phanareth, K. (Co-researcher), Purreskov , G. (Co-researcher), Svendsen, W. (Co-researcher), Polke-Pedersen, S. (Co-researcher), Kjær, A. L. (Co-researcher), Larsen, M. L. (Co-researcher), Storgaard, A. S. (Co-researcher), Holch Kristensen, B. (Principle researcher), Christensen, M. (Principle researcher), O’Neill , S. (Co-researcher) & Boesen , M. (Co-researcher)
01/11/22 → 22/12/23
Project: Development project/ Innovation
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How to build a Research Environment in 10 years from Ground Zero-The Biomedical Laboratory Scientist Colleges in Denmark
Smith, J. (Principle researcher), Ellegaard, M. (Co-researcher), Nordahl Madsen, H. (Co-researcher), Nøhr-Jensen, L. (Co-researcher), Mansilla Castano, F. (Co-researcher), Pristed, S. G. (Co-researcher) & Nielsen, L. K. (Co-researcher)
01/10/22 → 01/01/25
Project: Research
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Simple formula for adjusted performance parameters in evaluation of diagnostic methods
Frederik Banch, C., Lundquist, A. A., Urhammer, E., Rieneck, K. & Nielsen, L. K., Oct 2024, In: Transfusion. 64, 10, p. 2014-2018 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access -
Vitamin D Status and Physical Functioning in Nursing Home Residents after Improved Adherence to the Vitamin D and Calcium Recommendation: A Quasiexperimental Study
Mortensen, C., Beck, A. M., Tetens, I., Jeppesen, C., Jørgensen, S. F., Nielsen, L. K. & Kristensen, M., Oct 2024, In: Journal of Nutrition and Metabolism. 24, 1, 9 p., 2405429.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access -
Droplet digital PCR-based testing for donor-derived cell-free DNA in transplanted patients as noninvasive marker of allograft health: Methodological aspects
Clausen, F. B., Jørgensen, K. M. C. L., Wardil, L. W., Nielsen, L. K. & Krog, G. R., Feb 2023, In: PLoS ONE. 18, February, e0282332.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access -
Hunting for the elusive target antigen in gestational alloimmune liver disease (GALD)
Rieneck, K., Rasmussen, K. K., Schoof, E. M., Clausen, F. B., Holze, H., Bergholt, T., Jørgensen, M. H., Christensen, V. B., Almaas, R., Jordal, P. L., Locard-Paulet, M., Runager, K., Nielsen, L. K., Schlotmann, B. C., Weischenfeldt, J. L., Jensen, L. J. & Dziegiel, M. H., Oct 2023, In: PLoS ONE. 18, 10 October, e0286432.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access -
Bioanalytikere kan bidrage essentielt med deres kompetencer i forskning: En beretning fra bioanalytikerstuderende i forskningsmiljøet
Nielsen, S. K., Jahn, C. X. H., Skjødt, M.-O. & Nielsen, L. K., Jan 2022, In: Dbio. 2022, 1, p. 18-20 3 p.Research output: Contribution to journal › Journal article › Communication
Open AccessFile1426 Downloads (Pure)
Prizes
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Good Poster Award
Fenger, M. S. (Recipient), Frøstrup, A.-B. (Recipient), Larsen, A. S. (Recipient), Dahdouh, S. (Recipient), Zo El-Ghina, R. (Recipient), Nielsen, L. K. (Recipient) & Lorenzen, H. (Recipient), 28 Aug 2021
Prize
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2nd International Meeting on Cell-Free DNA
Nielsen, L. K. (Chairman)
28 May 2015 → 29 May 2015Activity: Participating in or organising an event types › Conference
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36th International congress of the International Society of Blood Transfusion (ISBT), Barcelona (virtual congress)
Nielsen, L. K. (Paricipant)
12 Dec 2020 → 16 Dec 2020Activity: Participating in or organising an event types › Conference
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3rd International Meeting on Cell-Free DNA
Nielsen, L. K. (Paricipant)
6 Apr 2017 → 7 Apr 2017Activity: Participating in or organising an event types › Conference
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4th International Meeting on Cell-Free DNA
Nielsen, L. K. (Chairman)
22 May 2019 → 24 May 2019Activity: Participating in or organising an event types › Conference
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Dansk selskab for klinisk immunologi (DSKI) generalforsamling og årsmøde 2017
Nielsen, L. K. (Paricipant)
8 Mar 2017 → 9 Mar 2017Activity: Participating in or organising an event types › Conference
Press/Media
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Projekt om måling af cellefrit DNA vinder bachelorpris
28/02/22
1 item of Media coverage
Press/Media: Press / Media
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