Raising the Bar in the Diagnosis of Non-Small Cell Lung Cancer (NSCLC): The Impact of Automated FISH Technology

Line Emilie Boje  Zakariasen; Mary Mathilde Knoblauch Fasting; Sys Johnsen; Svetlana Teplaia; Sanni Charlotte Pedersen; Filis Cramer Necip; Camilla   Qvist

Raising the Bar in the Diagnosis of Non-Small Cell Lung Cancer (NSCLC): The Impact of Automated FISH Technology

Line Emilie Boje Zakariasen
, Mary Mathilde Knoblauch Fasting
, Sys Johnsen
, Svetlana Teplaia
, Sanni Charlotte Pedersen
, Filis Cramer Necip
, Camilla Qvist

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The Met gene, which encodes a receptor tyrosine kinase, is crucial in cancer cell proliferation and survival. Fluorescence in situ hybridization (FISH) is vital for assessing MET-gene amplification in non-small cell lung cancer (NSCLC). Manual FISH assays are time-consuming and results are critical for treatment decision; automation could reduce turnaraound time. This study evaluates the potentional benefits of the automated FISH-system, Oncore Pro X (biocare Medical USA), by assessing factors including results, turnaround time, and cost.

Original language	English
Journal	International Journal of Biomedical Laboratory Science
Volume	14
Issue number	1
Pages (from-to)	24-38
ISSN	2308-7706
Publication status	Published - 2025

Cite this

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title = "Raising the Bar in the Diagnosis of Non-Small Cell Lung Cancer (NSCLC): The Impact of Automated FISH Technology",

abstract = "The Met gene, which encodes a receptor tyrosine kinase, is crucial in cancer cell proliferation and survival. Fluorescence in situ hybridization (FISH) is vital for assessing MET-gene amplification in non-small cell lung cancer (NSCLC). Manual FISH assays are time-consuming and results are critical for treatment decision; automation could reduce turnaraound time. This study evaluates the potentional benefits of the automated FISH-system, Oncore Pro X (biocare Medical USA), by assessing factors including results, turnaround time, and cost.",

author = "Zakariasen, \{Line Emilie Boje\} and Fasting, \{Mary Mathilde Knoblauch\} and Sys Johnsen and Svetlana Teplaia and Pedersen, \{Sanni Charlotte\} and Necip, \{Filis Cramer\} and Camilla Qvist",

year = "2025",

language = "English",

volume = "14",

pages = "24--38",

journal = "International Journal of Biomedical Laboratory Science ",

issn = "2308-7706",

publisher = "International Federation of Biomedical Laboratory Science",

number = "1",

}

Raising the Bar in the Diagnosis of Non-Small Cell Lung Cancer (NSCLC): The Impact of Automated FISH Technology. / Zakariasen, Line Emilie Boje ; Fasting, Mary Mathilde Knoblauch; Johnsen, Sys et al.
In: International Journal of Biomedical Laboratory Science , Vol. 14, No. 1, 2025, p. 24-38.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Raising the Bar in the Diagnosis of Non-Small Cell Lung Cancer (NSCLC)

T2 - The Impact of Automated FISH Technology

AU - Zakariasen, Line Emilie Boje

AU - Fasting, Mary Mathilde Knoblauch

AU - Johnsen, Sys

AU - Teplaia, Svetlana

AU - Pedersen, Sanni Charlotte

AU - Necip, Filis Cramer

AU - Qvist, Camilla

PY - 2025

Y1 - 2025

N2 - The Met gene, which encodes a receptor tyrosine kinase, is crucial in cancer cell proliferation and survival. Fluorescence in situ hybridization (FISH) is vital for assessing MET-gene amplification in non-small cell lung cancer (NSCLC). Manual FISH assays are time-consuming and results are critical for treatment decision; automation could reduce turnaraound time. This study evaluates the potentional benefits of the automated FISH-system, Oncore Pro X (biocare Medical USA), by assessing factors including results, turnaround time, and cost.

AB - The Met gene, which encodes a receptor tyrosine kinase, is crucial in cancer cell proliferation and survival. Fluorescence in situ hybridization (FISH) is vital for assessing MET-gene amplification in non-small cell lung cancer (NSCLC). Manual FISH assays are time-consuming and results are critical for treatment decision; automation could reduce turnaraound time. This study evaluates the potentional benefits of the automated FISH-system, Oncore Pro X (biocare Medical USA), by assessing factors including results, turnaround time, and cost.

M3 - Journal article

SN - 2308-7706

VL - 14

SP - 24

EP - 38

JO - International Journal of Biomedical Laboratory Science

JF - International Journal of Biomedical Laboratory Science

IS - 1

ER -

Raising the Bar in the Diagnosis of Non-Small Cell Lung Cancer (NSCLC): The Impact of Automated FISH Technology

Abstract

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