Simple formula for adjusted performance parameters in evaluation of diagnostic methods

In medical science, diagnostic methods are validated and evaluated using certain diagnostic performance parameters such as accuracy, sensitivity, specificity, positive predictive value, and negative predictive value,1, 2 see Box 1. In the presence of a reference method, these performance characteristics can easily be calculated to evaluate the performance of a new method. Such performance characteristics are also widely used for comparing one method with another method or to evaluate the performance of a methodology, for example, through comparative analysis such as systematical review or meta-analysis.3